pneumonia infection resulted in mainly in patients hospitalized patients receiving missiles at risk, "said Thomas Russo, MD, professor of medicine in the UB School of Medicine and Biomedical Sciences and Head of its Department of Infectious Diseases. "But in the last 10 to 15 years, a new version of this started cause of community acquired infections in young, healthy people," he says. "This option leads to serious, life-threatening, invasive infections and can spread to other organs from the original focus of infection."
Perhaps most important, says Russo, hypervirulent strains of these Klebsiella
pneumonia had the potential to become very resistant to antibiotics like
Escherichia coli and Klebsiella pneumonia classic. "These hypervirulent strains of these" superbakteriy "pending," he says. "If they become resistant to antibiotics, it will be difficult if not impossible to treat."
Given the recent funding from the National Institutes of Health under the program to fund high-risk, high reward research, Rousseau and his UB colleagues study a new variant of Microbiology
Klebsiella pneumonia in an attempt to identify genes that make it hypervirulent so they can figure out how to stop it in its path. "Infections caused by highly resistant bacteria is becoming more problematic," says Russo. "We are constantly threatened with" post-antibiotic "era. The combination of bacteria, which are both high virulence and resistance to antimicrobials is double trouble. " Concerns
research due to the fact that the classical Klebsiella pneumonia is a type of bacteria that can easily buy mobile genetic units called plasmids, which contain several genes that provide a high level of resistance to antimicrobial agents. "In particular, why we are concerned," says Russo. "We know that this bacterium has the potential to acquire these plasmids and that almost certainly will."
He notes that the majority of bacteria that were resistant to the majority of all drugs currently does not usually infect healthy members of the community. "What is alarming about hypervirulent pneumonia Klebsiella, that they have the potential to infect healthy people," says Russo. "If this hypervirulent bacteria become highly resistant to antibiotics, we have significant problems in management. We hope that our study and others may prevent such a possibility. "
Although the new hypervirulent variant was first shown exclusively in the Asia-Pacific region, it has now been found in several North American cities, including Buffalo, and in Europe, Canada, Israel and South Africa. UB researchers describe it as "not recognized" as physicians and microbiology laboratories. The disease usually manifests as liver abscess, which is not typical for healthy patients. "This new option presents unique features and scary: the first is a tendency to infect young, healthy people in society, and the second is its unique susceptibility to metastasis in other parts of the body," says Russo. "This applies to sites outside of the original source of infection, such as the lungs, central nervous system and eyes that can lead to vision loss. If infection spreads to the brain, there can be brain damage as well. From 10 to 30 percent of cases lead to death. "
In Buffalo, is hypervirulent variant >> << Klebsiella pneumonia was found in healthy, young man several years ago. The patient, who strattera no prescritpion was 20 years old, was hospitalized for several months before making a full recovery. These cases concern the entire international community of infectious diseases. Currently, in most cases hypervirulent
Klebsiella pneumonia decide if we consider aggressively with antibiotics and drainage of abscess, however, some infections, despite optimal treatment, resulting in permanent morbidity and death, says Russo. He notes that the potential for error to acquire drug resistance adding urgency to the work. Rousseau says that the microbiological laboratory should be aware that an important characteristic of these hypervirulent strains (also known as hypermucoviscous strains) that the bacterial colonies that grew on solid surfaces in the laboratory reached a common tool of microbiology is called a vaccination cycle, they form a viscous " ; line "more than 5 mm in length. Team Russo at UB now beginning to develop a clear picture of this huge bacterial enemy. In November, he and his colleagues published
PLoS ONE paper, showed that the hypervirulent Klebsiella pneumonia acquires iron more efficiently than conventional strains of K. pneumonia. "With NIH grant, we hope to further clarify the exact details of bacterial factors responsible for the hypervirulent
Klebsiella pneumonia acquisition of iron much more efficiently," he says. "The purpose of this line is that this iron acquisition factors had hypervirulent
Klebsiella pneumonia will themselves as therapeutic vaccines or targets so that we can better treat or prevent infection."
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